蛋白质及蛋白质复合物的结构和功能
基于结构的药物设计和研发
结构基因组学
蛋白质折叠
蛋白质三维结构模型构建
生物信息学

Morning Session on Nov. 9^th

*8:00 – 9:00*	*On-site Registration in SIBS*
09:00 – 10:15	Opening ceremony & conference photo Chair: Dr. Jianping Ding
	Presentations by invited speakers Chair: Dr. Timothy A. Springer
10:15 – 10:50	Symmetry and asymmetry in the life cycle of viruses Name: Michael G. Rossmann Institution: Purdue University, USA
10:50 – 11:25	HIV reverse transcriptase: high resolution crystal engineering, inhibitor strategic flexibility, and fragment screening Name: Eddy Arnold Institution: CABM and Rutgers University, USA
11:25 – 12:00	Insights into elegantly programmed nanomachines: Biophysical analysis of virus particles and their maturation Name: Jack Johnson Institution: The Scripps Research Institute, USA
*12:00 – 13:30*	*Lunch / Lunchtime seminars by Rigaku and Pfizer ( pizza, drink & gifts provided）*

Afternoon Session on Nov. 9^th

	Presentations by invited speakers Chair: Dr. Yigong Shi
13:30 – 14:05	Architecture of cyanobacterial photosystem II at 3 Å resolution: perspectives, conclusions and outlook Name: Wolfram Saenger Institution: Freie Universitat Berlin, Germany
14:05 – 14:40	Structures of cytochrome bc1 complexes and their functional implications Name: Di Xia Institution: National Institutes of Health, USA
14:40 – 15:15	Epigenetic link between DNA methylation and histone modifications Name: Xiaodong Cheng Institution: Emory University, USA
*15:15 – 15:45*	*Coffee break*
	Presentations by invited speakers Chair: Dr. Xiaodong Cheng
15:45 – 16:20	Ultraconserved nonsense: pervasive unproductive splicing of SR proteins associated with ultraconserved DNA elements Name: Steven E. Brenner Institution: University of California at Berkeley, USA
16:20 – 16:55	Structural Mechanisms of Transcriptional Silencing Name: Rui-Ming Xu Institution: New York University, USA
16:55 – 17:30	The mechanism of ribonuclease III action: how dicer dices Name: Xin-Hua Ji Institution: National Institutes of Health, USA
18:00– 19:00	*Rigaku: Reception (at Hope Hotel)*
19:00– 20:20	*Seminar by some of the sponsors (gifts provided)*
20:30– 21:30	Special session – - How to apply for a postdoctoral position overseas by Dr. Steven Brenner - Early career development in the academia by Dr. Yigong Shi - Early career development in the industry by Dr. Yuanhua Ding

Conference Program

Morning Session on Nov. 10^th

	Presentations by invited speakers Chair: Dr. Steven E. Brenner
08:30 – 09:05	Conformational change and ligand binding in integrins Name: Timothy A. Springer Institution: Harvard University, USA
09:05 –09:40	Structural Insights into Regulated Intramembrane Proteolysis Name: Yigong Shi Institution: Princeton University, USA
09:40 –10:15	Structure and function studies of serum amyloid P component recognition by Fcγ receptors Name: Peter D. Sun Institution: National Institutes of Health, USA
*10:15 – 10:45*	*Coffee break*
	Presentations by invited speakers Chair: Dr. Eddy Arnold
10:45 – 11:20	Exploring Biological and Chemical Space with High-throughput Crystallography: The New Dimensions of Drug Discovery Name: Tom Blundell Institution: University of Cambridge, UK
11:20 – 11:40	Building an integrated structural biology platform to address challenges in drug discovery Name: Yuanhua Ding Institution: Pfizer, USA
11:40 – 11:55	The PDB as a resource for modern biological research Name: Zukang Feng Institution: RCSB PDB, Rutgers University, USA
*12:00 – 13:30*	*Lunch / Lunchtime seminars by GE Healthcare and TTP LabTech ( pizza, drink & gifts provided）*

Afternoon Session on Nov. 10^th

	Presentations by invited speakers Chair: Dr. Rui-Ming Xu
13:30 – 14:05	Structural aspects of SNARE - botulinum neurotoxin interactions Name: Axel Brünger Institution: Stanford University, USA
14:05 – 14:40	Structure and function of human proteins in cell junction Name: Yunyu Shi Institution: University of Science of Technology of China, China
14:40 – 15:15	Structural studies of fatty acid metabolism and relevance to the obesity epidemic Name: Liang Tong Institution: Columbia University, USA
15:15 – 15:50	Synchrotron-Based Structural Proteomics of Vesicle Transport: Rab Activation and Effector Interaction, and Ubiquitin Recognition Name: Soichi Wakatsuki Institution: Photon Factory and Structural Biology Research Center，KEK, Japan
15:50 –18:30	Poster presentations
*19:00-21:00*	*Pfizer:* *Conference banquet & award announcement (at Pearl Restaurant)*

Conference Program

Morning Session on Nov. 11^th

	Presentations by plenary session speakers Chair: Yuequan Shen
09:00 – 09:35	Structure of human synbindin reveals two conformations and a novel binding region in its PDZ-like domain Name: Weiming Gong Institution: Institute of Biophysics, CAS
09:35 –10:10	Multifunctional transcriptional co-activator p100 is involved in splicing: functional and structural basis Name: Zhi-jie Liu Institution: Institute of Biophysics, CAS
*10:10 – 10:40*	*Coffee break*
10:40 – 11:15	Functional roles of human MRG15 and its homologues in histone modification and transcription regulation Name: Jianping Ding Institution: Institute of Biochemistry and Cell Biology, SIBS, CAS
11:15 – 11:50	Functional Protein Design Targeting Protein-Protein Interface Name: Luhua Lai Institution: Peking University
*12:00 – 13:30*	*Lunch*

Afternoon Session on Nov. 11^th

	Presentations by plenary session speakers Chair: Weiming Gong
13:30 – 14:05	Analysis from the Tissue Specificity to Function Enrichment by MiRNA Microarray Name: Yixue Li Institution: Shanghai Institutes for Biological Sciences, CAS
14:05 – 14:40	Target Identification Using Small Molecules as Probes Name: Hualiang Jiang Institution: Shanghai Institute of Materia Medica, CAS
14:40 – 15:15	Solving Enzyme Structures by Metabolic Pathways Name: Xiaodong Su Institution: Peking University
*15:15 – 15:45*	*Coffee break*
15:45 – 16:20	How does one receptor accommodate two ligands? Crystal structure of urokinase receptor in complex with urokinase and vitronectin Name: Mingdong Huang Institution: Fujian Institute of Research on the Structure of Matter, CAS and Harvard University, USA
16:20 –16:55	Protein structures and functions studied via synchrotron radiation methods Name: Yuhui Dong Institution: Institute of High Energy Physics, CAS
16:55 –17:30	Insulin-degrading enzyme Name: Yuequan Shen Institution: Nankai University
*18:30-20:30*	*Dinner at Hongqiao Restaurant*

组织单位

主办单位

中国科学院上海生命科学研究院生物化学与细胞生物学研究所中国科学院北京生物物理研究所清华大学南开大学中国晶体学会

支持单位

中华人民共和国科学技术部

国家自然科学基金委员会

中国科学院

上海市科学技术委员会

承办单位
待定

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蛋白质及蛋白质复合物的结构和功能基于结构的药物设计和研发结构基因组学蛋白质折叠蛋白质三维结构模型构建生物信息学

Structural Insights into Regulated Intramembrane Proteolysis

蛋白质及蛋白质复合物的结构和功能
基于结构的药物设计和研发
结构基因组学
蛋白质折叠
蛋白质三维结构模型构建
生物信息学