If you’re interested in making keynote speech or oral report in IWMH2018, please send your latest CV, speech title and abstract to iwmh@a-scie.org, we will reply you in 3 days. After verification, we will send you invitation letter and keep you noted with the proceeding of conference.
Look forward to future correspondence with all of scholars and experts in medicine and health management.

Keynote Speaker

Jean-Marie Aerts

Professor

Faculty of Bioscience Engineering, KU Leuven, Belgian

Title: Monitoring and controlling of complex biological systems: challenges and lessons learned

Abstract: Thanks to the ever growing possibilities in terms of sensors and sensing systems and the ever increasing computing power, the possibilities for measuring and processing biological signals in real-time have significantly grown during the last two decades. As a consequence, it becomes more and more realistic to apply schemes of model-based monitoring and control to biological systems in practice. However, unlike many mechanical systems, biological systems are very complex, individually different, time-varying and dynamic, making the management (i.e. monitoring and/or control) of these systems often very challenging.
A first challenge is to model these biological systems using compact, accurate and biologically meaningful models that can be applied in monitoring and controlling schemes. It is argued that dynamic data-based mechanistic modelling approaches are potential candidates for model-based management of biological systems. A second challenge is to extract model features that can be used as biomarkers for monitoring the status of individual biological systems. A third challenge is to define proper control targets that take into account the physiological/physical boundary conditions of the considered biological system.
These challenges will be illustrated using examples of a wide variety of biological systems, ranging: from cellular up to organism level, from animal to human applications and from physiological to mental processes. The main lessons learned will be discussed and future research needs will be identified.

Long Ba

Professor

State Key Laboratory of Bioelectronics, School of Biology and Medical Engineering, Southeast University, Nanjing, China

Title: Non-invasive wearable blood pressure monitoring based on flexible strain sensor and Artery Tonometry

Abstract: A wearable pulse wave and blood pressure monitoring system was designed and fabricated based on flexible strain sensor and micro-actuator. The flexible strain sensor was fabricated by using a surface structured elastomer with electric conducting surface layer as gate electrode of a vertical field effect transistor. This strain sensitive vertical transistor exhibits excellent strain sensitivity and repeatability within the stress range below 100kPa. The flexible sensor enables compact contact to the deformable epidermal artery and quantitative pressure sensing to the pulse wave. The micro-actuator was designed and fabricated based on shape memory alloy (SMA) elements, which is controlled through a power electronic circuit programmed by microcontroller unit (MCU). The whole system was fabricated and integrated on the flexible printed circuit board with strain sensor pressured by micro-actuator on the radial artery. The systolic and diastolic blood pressure was obtained according to the artery tonometry method and compared with the results from sphygmomanometer. By calibrating the sensor and the tonometry cofficients using either cuff or micro-acuator, the measured errors can be as small as several mmHg. The data were transmitted to personal mobil data terminal through Bluetooth protocols for data processing, storage, display and uploading. The system demonstrates the capability of wide applications from healthcare maintenance to continuous cardiovascular disease diagnose.

Hui Sun

Tenured full professor

Chinese Academy of Science, Beijing, China

Title: Human Cadaver Retina Model for Retinal Heating During Corneal Surgery with a Femtosecond Laser
Abstract: Purpose: Femtosecond lasers are widely used in everyday clinical procedures to perform minimally invasive corneal refractive surgery. The Intralase femtosecond laser (AMO Corp. Santa Ana, CA) is a common example of such a laser. In the present study a numerical simulation was developed to quantify the temperature rise in the retina during femtosecond intracorneal (Intralase) surgery. Also, transmission measurements were performed on the excised human fundus. Additionally, ex-vivo retinal heating due to IntraLase irradiation was measured with an infrared thermal camera (Fluke corp. Everett, WA) as a validation of the simulation.
Methods: A computer simulation was developed using Comsol Multiphysics and Matlab to calculate the temperature rise in the retina during Intralase surgery. Human retinas were excised from two eyes and transmission measurements with a 60kHz Intralase machine were performed. 4 human retinas were irradiated with a 150kHz Intralase and the temperature rise was measured with an infrared thermal camera.
Results: The simulation showed a temperature rise of less than 0.3 degrees for realistic pulse energies for the various repetition rates. Thermal camera measurements are in agreement with the simulation.
Conclusions: During routine Intralase surgery with normal clinical parameters, the temperature rise is well beneath the threshold for retina damage. The simulation predictions are in agreement with thermal measurements providing a level of experimental validation.

Chen Bin

Professor

Xi'an Jiaotong University, Xi'an, China

Title: New strategy for Laser Dermatology: microvascular responses to 755nm Alexandrite lasers, 595nm pulse dye laser and 1064nm Nd:YAG laser
Abstract: Port Wine Stain birthmarks (PWS) are congenital vascular birthmarks that occur in approximately 0.3% of children. Histopathological analysis of PWS reveals a normal epidermis overlying an abnormal plexus of benign vascular malformations consisting of ectatic capillaries of diameters varying from 10 to 300 μm. Based on the selective photothermolysis theory, laser therapy is the most commonly utilized treatment for PWS. The pulsed dye laser (PDL) with a wavelength of 585 or 595 nm is most often used, however less than 20% patients exhibit complete clearing due to the shallow penetration and competitive absorption between epidermal melanin and dermal hemoglobin. The long pulsed Nd:YAG laser with a wavelength of 1064 nm allows for tissue penetration of up to 5 to 6 mm. However, high incident energy density caused by low absorption of hemoglobin increases risk of collagen damage and subsequent scarring. In comparison, the 755-nm Alexandrite laser has a higher absorption than 1064nm Nd:YAG laser, and deeper penetration then 585/595nm PDL, which shows great potential in laser treatment of PWS.
In this study, an animal model study by dorsal skin chamber and numerical simulations were conducted to compare blood vessel thermal responses to irradiation by 755nm laser with 585/595 nm PDL and the 1064 nm Nd:YAG laser. In the in vivo experiment, the laser was triggered with the aiming beam directly overlying the target blood vessels of the Danforth’s short tail (SD) mouse. After each irradiation, the immediate blood vessel effects were qualitatively examined using the microscopy camera. Numerical simulations of the light transport and heat diffusion in skin tissue were conducted by Monte Carlo method and discrete-blood-vessel model. A series of thermal effects were observed after irradiation, including blood coagulation, diameter decrease, complete constriction, hemorrhage and collagen damage. The thermal effect, rate of hemorrhage and collagen damage and heating pattern of 755nm laser were all between these of 595nm PDL and 1064nm Nd: YAG laser. Compared with the 595 nm laser, 755 nm laser what is easy to cause target vessel to produce disappearance has a good bleaching effect with less hemorrhage happening. Excessive incident energy should be avoided to generate the bad phenomena such as hemorrhage and collagen damage.

Lukui Chen

Professor

Department of Neurosurgery, Zhongda Hospital Southeast University, Nanjing, China

Title: Comparative analysis of microRNA expression profiles of exosomes derived from normal and ischemic preconditioning human neural stem cells by next generation sequencing
Abstract: Stroke recovery is associated with neural stem cell (NSC) development and neurovascular unit reconstruction. Exosomes, as important intercellular players in neurovascular communication, mediate neuro-restorative events by transferring exosomal protein and RNA cargoes. In order to study the role of exosomal microRNAs (miRNAs) in human NSCs (hNSCs), we analyzed the expression profiles of miRNAs in hNSC-derived and ischemic preconditioning hNSC-derived exosomes by next generation sequencing (NGS). The results showed that a certain proportion of miRNAs were differentially expressed in both exosomes. In addition, target gene prediction and Gene Ontology (GO) enrichment analysis showed that these genes associated with differential miRNAs primarily participated in biological process, cellular component, and molecular function. Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment data suggested that most of targeted genes were involved in PI3K-Akt, Hippo, MAPK, mTOR, and Endocytosis etc. signaling pathways. Then we identified the interesting and important expressed miRNA and considered that miR-98-3p might be a special hNSC-derived exosomal-miRNA which were significantly downregulated under ischemic preconditioning. hNSCs-derived exosomes were promising in modulating gene expression or in stroke therapy, and after ischemic preconditioned, the functions of these exosomes were changed, such as exosomal-miRNAs expression profile difference. In summary, our study suggested that hNSC-derived exosomal miRNAs including ischemic preconditioning exosomal miRNAs will provide a new strategy for the diagnosis and treatment of stroke patients.